Lakers center Deandre Ayton to miss game tonight against Clippers

  • Broderick Turner
  • November 25, 2025
The Lakers will be without their starting center tonight, as Deandre Ayton has been ruled out for the matchup against the Clippers, a development that reshapes both the rotation and the tone of this latest installment of the hallway rivalry.

Losing Ayton removes the Lakers’ primary interior presence on both ends of the floor. His size, touch around the rim, and ability to anchor the paint have been central to how the Lakers structure their half-court defense and pick‑and‑roll offense. Without him, the coaching staff will be forced to lean more heavily on smaller lineups, backup bigs, or a committee approach to rebounding and rim protection.

The Clippers, who like to toggle between perimeter-heavy attacks and more deliberate half-court sets, will likely test the Lakers inside early. The absence of a true starting-caliber center can invite more drives, post touches, and second-chance opportunities if the Lakers cannot control the glass. This shifts added responsibility onto the forwards, who must help contain penetration and finish defensive possessions with rebounds.

From a league-wide perspective, Ayton’s absence underscores how fragile frontcourt depth can be in an era increasingly dominated by perimeter play. Teams still depend on reliable size to survive the physical demands of an 82-game season and the nightly challenge of defending elite bigs and downhill guards. When a starting center sits, it often exposes how thin the margin is between a cohesive defensive scheme and a scrambling unit trying to compensate.

For the Lakers, tonight becomes an early test of adaptability. It is a chance for reserve big men to carve out larger roles and for the coaching staff to experiment with more switchable, spread-lineup configurations. Offensively, they may lean further into pace, spacing, and drive-and-kick actions to offset the loss of a traditional interior target.

While it is only one game, how the Lakers respond without Ayton could offer a preview of their resilience and tactical flexibility as the season unfolds.